Synergistic neutralization of HIV-1 by human monoclonal antibodi

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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4241881, 4241421, 4241481, 4241601, 435 7021, 435346, 5303873, A61K 3921, C12P 2104, C12P 2108

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active

059223251

ABSTRACT:
A synergistic combination of antibodies specific for HIV envelope glycoprotein gp120 is described. One of the antibodies specific for the V3 loop and the other is specific for the CD-4 binding site of gp120.

REFERENCES:
patent: 4725669 (1988-02-01), Essex et al.
patent: 4772547 (1988-09-01), Heimer et al.
patent: 4863730 (1989-09-01), Karpas
patent: 5087557 (1992-02-01), McClure
patent: 5166050 (1992-11-01), Shriver et al.
Olshevsky, U., et al., "Identification of Individual Human Immunodeficiency irus Type 1 gp120 Amino Acids Important for CD4 Receptor Binding," 64 (12) J. Virol. 5701-07 (1990).
Javaherian, et al., "Broadly Neutralizing Antibodies Elicited By the Hypervariable Neutralizing Determinant of HIV-1," 250 Sci. 1590-93 (1990).
LaRosa, G.J., et al., "Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant," 249 Sci. 932-35 (1990).
Scott, C.F., et al., "Human Monoclonal Antibody That Recognizes the V3 Region of Human Immunodeficiency Virus gp120 and Neutralizes the Human T-Lymphotropic Virus Type III .sub.MN Strain," 87 Proc. Natl. Acad. Sci. USA 8597-8601 (1990).
Zolla-Pazner, S., et al., "Production of Human Monoclonal Antibodies Against the V3 Loop of gp120," Sixth Intl. Conf. on AIDS (Abstract, Th.A. 75) (San Francisco, CA 1990).
Sun, N., et al., "Generation and Characterization of Monoclonal Antibodies to the Putative CD4-Binding Domain of Human Immunodeficiency Virus Type 1 gp120," 63 (9) J. Virol. 3579-3585 (1989).
Lasky, L.A., et al., "Delineation of a Region of the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein Critical for Interaction With the CD4 Receptor," 50 Cell 975-85 (1987).
Robinson, et al., "Antibodies to the Primary Immunodominant Domain of Human Immunodeficiency Virus Type 1 (HIV-1) Glycoprotein gp41 Enhance HIV-1 Infection In Vitro," 64(11) J. Virol. 5301-05 (1990).
Ho, et al., "Conformational Epitope on gp120 Important in CD4 Binding and Human Immunodeficiency Virus Type 1 Neutralization Identified by a Human Monoclonal Antibody," 65(1) J. Virol. 489-93 (1991).
Posner, M., et al., "Development of an IgG-1 Human Monoclonal Antibody That Neutralizes HIV1 Infectivity and Binding and Reacts With a Cell Surface Antigen Expressed by HIV1 Infected Cells," Sixth Intl. Conf. on AIDS, 153 (Abstract, Th.A.77 (San Francisco, CA 1990).
Robert-Guroff, M., et al., "HTLV-III-Neutralizing Antibodies in Patients with AIDS and AIDS-Related Complex," 316 Nature 72-74 (1985).
Weiss, R.A., et al., "Neutralization of Human T-Lymphotropic Virus Type III By Sera of AIDS and AIDS-Risk Patients," 316 Nature 69-71 (1985).
Rook, A.H., et al., "Sera From HTLV-III/LAV Antibody-Positive Individuals Mediate Antibody-Dependent Cellular Cytotoxicity Against HTLV-III/LAV-Infected T Cells," 138 J. Immunol. 1064-1067 (1987).
Ljunggren, K., et al., "Antibody-Dependent Cellular Cytotoxicity-Inducing Antibodies Against Human Immunodeficiency Virus," 139 J. Immunol. 2263-67 (1987).
Ho, D.D., et al., "Human Immunodeficiency Virus Neutralizing Antibodies Recognize Several Conserved Domains on the Envelope Glycoproteins," 61(6) J. Virol. 2024-38 (1987).
Devash, et al., "Vertical Transmission of Human Immunodeficiency Virus is Correlated With the Absence of High Affinity/Avidity Maternal Antibodies to the gp120 Principal Neutralizing Domain," 87 Proc. Natl. Acad. Sci. USA 3445-49 (1990).
Homsy, J., et al., "Antibody-Dependent Enhancement of HIV Infection," The Lancet 1285-86 (Jun., 1988).
Takeda, A., et al., "Antibody-Enhanced Infection By HIV-1 Via Fc Receptor-Meditated Entry," 242 Sci. 580-83 (1988).
Jouault, et al., "HIV Infection of Monocytic Cells: Role of Antibody-Mediated Virus Binding to Fc-Gamma Receptors," 3(3)AIDS 125-133 (1989).
Karpas, A., et al., "Effects of Passive Immunization In Patients With the Acquired Immunodeficiency Syndrome-Related Complex and Acquired Immunodeficiency Syndrome," 85 Proc. Natl. Acad. Sci. USA 9234-37 (1988).
Emini, et al., "Antibody-Mediated In Vitro Neutralization of Human Immunodeficiency Virus Type 1 Abolishes Infectivity for Chimpanzees'" 64(8) J. Virol. 3674-78 (1990).
Girard, et al., "Immunization of Chimpanzees Confers Protection Against Challenge With Human Immunodeficiency Virus," 88 Proc. Natl. Acad. Sci, USA 542-46 (1991).
Berman, et al., "Protection of Chimpanzees from Infection by HIV-1 After Vaccination with Recombinant Glycoprotein gp120 But Not gp160," 345 Nature 622-25 (1990).
Gerna, et al., "Synergistic Neutralization of Rubella Virus by Monoclonal Antibodies to Viral Haemagglutinin," 68 J. Gen. Virol. 2007-2012 (1987).
Volk, W.A., et al., "Monoclonal Antibodies to the Glycoprotein of Vesicular Stomatitis Virus: Comparative Neutralizing Activity," 42 (1) J. Virol. 220-27 (1982).
Peiris, J. S. M., et al., "Monoclonal Antibodies Against the Flavivirus West Nile," 58 J. Gen Virol. 283-89 (1982).
Cle gg, et al., "Conformational Changes In Sindbis Virus E1 Glycoprotein Induced By Monoclonal Antibody Binding," 64 J. Gen. Virol. 1121-1126 (1983).
Kimura-Kuroda, J., et al., "Topographical Analysis of Antigenic Determinants on Envelope Glycoprotein V3 (E) of Japanese Encephalitis Virus, Using Monoclonal Antibodies," 43(1) J. Virol. 124-32 (1983).
Kingsford, "Enhanced Neutralization of La Crosse Virus By the Binding of Specific Pairs of Monoclonal Antibodies to the G1 Glycoprotein," 136 Virol. 265-73 (1984).
Russell, P.H., "The Synergistic Neutralization of Newcastle Disease Virus By Two Monoclonal Antibodies To Its Haemagglutinin-Neuraminidase Protein," 90 Arch. Virol. 135-44 (1986).
Anderson, et al., "Neutralization of Respiratory Syncytial Virus by Individual and Mixtures of F and G Protein Monoclonal Antibodies," 62(11) J. Virol. 4232-38 (1988).
Dubuisson, et al., "Neutralization of Bovine Herpevirus Type 4 By Pairs of Monoclonal Antibodies Raised Against Two Glycoproteins and Identification of Antigenic Determinants Involved in Neutralization," 71 J. Gen. Virol. 647-653 (1990).
Chou, "The Median-Effect Principle and the Combination Index for Quantitation of Synergism and Antagonism," Synergism and Antagonism in Chemotherapy, 61-102 (San Diego, CA 1991).
Lussenhop, N.O., et al., "Epitope Analysis of Human Cytomegalovirus Glycoprotein Complexes Using Murine Monoclonal Antibodies," 164 Virol. 362-372 (1988).
Layne, S.P., et al., "Quantifying the Infectivity of Human Immunodeficiency Virus," 86 Proc. Natl. Acad. Sci. USA 4644-48 (1989).
Gorny, M.K., et al., "Generation of Human Monoclonal Antibodies To Human Immunodeficiency Virus," 86 Proc. Natl. Acad. Sci. USA 1624-28 (1989).
Tilley, S.A., et al., "A Human Monoclonal Antibody Against the CD4 Binding Site of HIV-1 gp120 Exhibits Potent, Broadly Neutralizing Activity," 142 Res. Virol. 247-259 (Paris 1991).
Kieny, M.P., et al., "Improved Antigenicity of the HIV env Protein By Cleavage Site Removal," 2(3) Protein Eng. 219-225 (1988).
Leonard, C.K., et al., "Assignment of Intrachain Disulfide Bonds and Characterization of Potential Glycosylation Sites of the Type 1 Recombinant Human Immunodeficiency Virus Envelope Glycoprotein (gp120) Expressed in Chinese Hamster Ovary Cells," 265 J. Biol. Chem. 10373-10382 (1990).
Gurgo, C., et al., "Envelope Sequences of Two New United States HIV-1 Isolates," 4164 Virology 531-36 (1988).
Harada, S., et al., "Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay," 229 Sci. 563-66 (1985).
Robinson, J.E., et al., "Identification of Conserved and Variant Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 by Human Monoclonal Antibodies Produced by EBV-Transformed Cell Lines," 6 (5) AIDS Res. Human Retroviruses 567-79 (1990).
Ho, D.D., et al., "A Neutralizing Human Monoclonal Antibody (HMab) Identifies an Epitope Within the Putative CD4-Binding Domain (CD4-BD) of HIV-1 gp120," Sixth Intl. Conf. on AIDS. 152 (CA 1990).
Gallo, R., et al., "Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and At Risk for AIDS," 224 Sci. 500-503 (1984).
Berzofsky, J.A., et al. "Antigen-Antibody Interactions and Monoclonal Antibodies," Fundamen

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