Synergistic mixtures of selected amino acids

Details Synergistic mixtures of selected amino acids Synergistic mixtures of selected amino acids

2002-05-16

2004-02-17

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

C424S630000, C424S631000, C424S632000, C424S633000, C424S634000, C424S635000, C424S637000, C514S532000, C514S534000, C514S538000, C514S551000, C514S561000, C514S563000, C514S567000, C514S499000, C514S500000

Reexamination Certificate

active

06692774

ABSTRACT:

INTRODUCTION
The present invention concerns synergistic fungicidal mixtures. The present invention more particularly concerns synergistic mixture of &bgr;-aminobutyric acid (hereinafter referred to as BABA) and its N-benzoyl-octyl ester derivatives for the control of plant diseases.
BACKGROUND OF THE INVENTION
Fungicides are often combined in mixtures for 3 main reasons: 1. to widen the spectrum of antifungal activity to control several diseases occurring simultaneously in a crop 2. to exploit synergistic interaction between fungicides, by which the overall activity is increased and the concentration of the compounds reduced, and 3. to delay the selection process of resistant fungal individuals to one component of the mixture (Gisi, Phytopathology 86 1273-1279, 1996).
Avoidence of plant disease in agricultural production may be accomplished not only by using fungicides or fungicidal mixtures but also by using “plant activators”, molecules which enhance the natural resistance (defense) of the plant. Such activators which have no direct fungicidal effect on the pathogen (Ryals et al The Plant Cell 8: 1809-1819, 1996), induce systemic acquired resistance (SAR) in the plant several days after application (Ibid).
To date only few molecules were reported to induce SAR in crop plants viz. salicylic acid (SA), 2,6-dichloroisonicotinic acid (INA) benzol (1,2,3) thiadiazole-7-carbothiouic acid S-methyl ester (BTH) (Ibid), and DL-3-amino butyric acid (BABA, Cohen et al Plant Physiology 104: 56-59, 1994).
However whereas SA, INA or BTH have to be applied to the crop ahead of infestation (Ryals, et al Ibid) BABA can be applied post—infectionaly (Cohen et al Ibid).
The idea behind the present invention is to combine two methods of disease control—the direct—kill method operating on the target pathogen and the indirect method of activating the natural defense approach of the crop plant. Such two methods are combined by using mixtures of a fungicide or fungicides (direct—kill) with BABA or its N-benzoyl-octyl ester derivative(SAR).
We show here that such mixtures are synergistic in controlling plant diseases.
OBJECTIVES OF THE INVENTION
It is the objective of the present invention to provide novel mixtures of fungicides of &bgr;-aminobutyric acids. It is an objective of the present invention to provide a synergistic mixture of BABA and/or its N-benzoyl-octyl ester derivative with various other fungicides.
SUMMARY OF THE INVENTION
In accordance with the present invention there is provided synergistic fungicidal compositions comprising one or more compounds selected from Group A and one or more compounds selected from Group B, wherein the compounds of Group A are selected from the group consisting of DL-3 aminobutyric-acid and its N-Benzoyl octyl ester, and the compounds of Group B are selected from the group consisting of fosetyl aluminum, dimethomorph, a mixture of folpet and ofturace (45:5), folpet, fencaramid (Bayer SZX), mancozeb, cymoxanil, methalaxyl, the single optical isomer of metalaxyl, a mixture of cymoxamil and mancozeb (4:1), copper sulfate, copper hydroxide, copper sulfate hydrate, azoxystrobin, and acibenzolar-s-methyl.
The present invention also provides an improved method of controlling fungi, especially late blight and downy mildews, applying to the plant a composition containing an effective amount of one of these mixtures. The present invention further provides an improved method of controlling
phytophthora infertan
in potato or tomatoe,
Pseudoperonospora cubensis
in cucumber or melon,
Plasmopera viticola
in grapes, and
Peronospora tabacina
in tabacco.


REFERENCES:
patent: WO 95/15684 (1995-06-01), None
patent: WO 96/22690 (1996-08-01), None
Cohen, Yigal, “Local and systemic control of Phytophthora infestans in tomato plants by DL-3-amino-n-butanoic acids,” Phytopathology, vol. 84, No. 1, 1993, pp. 5-59.*
The Agrochemicals Handbook, The Royal Society of Chemistry, Unwin Brothers Ltd., Old Working, Surrey, United Kingdom, 1983, p. A245/Oct. 83.*
Ryals et al., “Systemic Acquired Resistance”, The Plant Cell, vol. 8, pp. 1809-1819, 1996.
Gisi et al., “Synergistic Interaction of Fungicides in Mixtures”, Pyhtopathology, vol 86, No. 11, pp. 1273-1279, 1996.
Cohen et al., “&bgr;-Aminobutyric Acid Induces the Accumulation of Pathogenesis-Related Proteins in Tomato (Lycopersicon esculenttumL.) Plant and Resistance to Late Blight Infection Caused byPytophthora infestans”, Plant Physoil., vol. 104, pp. 59-66, 1994.
Tomlin, “The Pesticide Manual Incorporating the Agricultural Handbook”, 10thEd. pp. 635-636, 1995.

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