Synergistic effect of chemotherapeutic agents on beta-interferon

Details Synergistic effect of chemotherapeutic agents on beta-interferon Synergistic effect of chemotherapeutic agents on beta-interferon

1984-10-22

1986-02-04

Gron, Teddy S.

Drug, bio-affecting and body treating compositions

Lymphokine

424251, 435811, A61K 3900, A61K 4502

Patent

active

H00000221

ABSTRACT:
A composition of matter exhibiting a synergistic cytotoxic effect in combination therapy of certain breast cancer and myeloma cell lines is prepared by combining synergistically effective amounts of 5-fluorouracil and human recombinant beta-interferon, optionally together with a pharmaceutically effective diluent or carrier. Preferably the recombinant beta-interferon is a mutein in which the cysteine residue at position 17 of native beta-interferon is replaced by a serine residue.

REFERENCES:
Yamamoto et al., Cancer Letters, vol. 20, pp. 131-138, 1983.
Miyoshi et al., Cancer Letters, vol. 17, pp. 239-247, 1983.
Eppstein et al., Biochem. Biophys. Res. Comm., vol. 120, pp. 66-73, 1984.

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