Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-05-13
2008-05-13
Solola, Taofiq (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07371779
ABSTRACT:
A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R1and R2is H and the other is selected from OR4, SR4and NHR4, wherein R4is H or 1-6C alkyl, or R1and R2together with the carbon atom to which they are joined form a keto group, and R3is a straight or branched chain, saturated or unsaturated aliphatic hydrocarbyl group containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR5R6wherein each of R5and R6is selected from H and 1-6C alkyl or R5and R6together with the N atom form a morpholino or piperazino group, or any enantiomer thereof; and at least one compound of the formula (III): wherein R7is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing from 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR12R13, wherein each of R12and R13is independently selected from H and 1-6C alkyl or R12and R13together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino; R8is a group selected from H, —OH, halo, —CHO, —CO2H and CONHR14wherein R14is H or a 1-6C alkyl; each of R9, R10and R11is independently selected from H, —CH3, —OCH3and halo; or a non-toxic pharmaceutically-acceptable salt thereof. The determined immunosuppressant activity of the composition is greater than the sum of the activities of the individual components of the composition when determined separately
REFERENCES:
patent: WO 95/01175 (1995-01-01), None
patent: WO 01/74801 (2001-10-01), None
patent: WO 02/47686 (2002-06-01), None
patent: WO 03/004017 (2003-01-01), None
Bozicevic Field & Francis LLP.
Field Bret E.
Solola Taofiq
The Secretary of State for Defense Science and Technology
LandOfFree
Synergistic compositions of N-acylhomoserine lactones and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synergistic compositions of N-acylhomoserine lactones and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synergistic compositions of N-acylhomoserine lactones and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2793366