Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Peroxide or compositions of or releasing gaseous oxygen or...
Utility Patent
1998-04-24
2001-01-02
Pak, John (Department: 1616)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Peroxide or compositions of or releasing gaseous oxygen or...
C424S126000, C514S183000, C514S211070, C514S212010, C514S218000, C514S277000, C514S430000, C514S431000, C514S449000, C514S450000, C514S557000, C514S579000, C514S644000, C514S663000, C514S665000, C514S667000, C514S672000, C514S673000, C514S674000, C514S715000, C514S717000, C514S718000, C514S719000, C514S720000, C514S722000, C514S723000, C514S727000, C514S772000, C514S772100, C514S788000, C514S970000, C514S975000
Utility Patent
active
06168808
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to novel disinfectant compositions containing peracetic acid.
BACKGROUND OF THE INVENTION
Such solutions are nowadays widely used in many industrial sectors. The increasing interest in peracetic acid lies in its wide range of biocidal activity, in particular with respect to bacteria, algae, yeasts, moulds, fungi and viruses. However, dilute solutions of peracetic acid are of insufficient wetting performance on the surfaces commonly treated, for example in the medical and hospital fields, in the agrifood, pharmaceutical, cosmetics and microelectronics industries, bioindustries, collectives and, more generally, in any activity for which controlling the population of microorganisms is required. The surfaces to be treated are very diverse; mention may be made, for example, of premises, equipment, apparatus, tools and utensils, containers such as tanks, package wrapping and pipes. It has thus been sought to lower the surface tension of these disinfectant solutions by adding surfactants. Among the documents of the prior art, mention may be made in particular of those which describe compositions containing a peracid and a nonionic surfactant, for instance the international patent applications published under the numbers WO 88/08667, WO 93/10088 and WO 94/14321 or European patent applications EP 193,416 and EP 596,493.
However, none of the peracetic acid-based disinfectant solutions described in that prior art has the set of properties required in order to be commercially acceptable; these properties are as follows: the solution should contain both peracetic acid and the surfactant, it should be stable over time, it should have a high wetting power and a low foaming power, it should be easily rinsable, be clear in appearance, it should contain minimum amounts of chemical products, while at the same time being sufficiently active on microorganisms after dilution, and, lastly, the surfactant(s) used should be compatible with peracetic acid. Furthermore, when it is a matter of disinfecting and sterilizing equipment, it is essential for the disinfectant solution to have improved fungicidal activity. This requirement is unavoidable where medico-surgical activities are concerned such as, for example, endoscopy, both interventional and exploratory, which is in full development. Indeed, it may thus be feared that a multiplication of endoscopic interventions might be accompanied by a multiplication of post-endoscopic infections. For this reason, the disinfection procedures to be applied to reusable medical equipment are of great importance in protecting both patients and the care staff against the risks of infection.
Among reusable medical equipment, flexible endoscopes are particularly expensive. Given the limited number of these items of equipment in hospitals, their reuse is increasingly frequent and, consequently, the delay between two interventions is increasingly short. For this reason, these practices give rise to new disinfection procedures characterized mainly by their simplicity, their speed and their reduced cost.
However, the use of peracetic acid alone, as fungicidal agent, requires high effective doses. Usually, the solutions lack remanence. This has given rise to interest in reinforcing them by adding a fungicidal agent in order to increase the longevity of disinfectant baths and to reduce the effective doses to be used.
Antimicrobial active principles have different modes of action. In general, they act either on the intracellular constituents (enzymes, mitochondria, etc.) or on the extracellular constituents (cytoplasmic membrane and cell wall). Compounds which act inside the cell must, in order to reach their target, cross the barrier formed by the cytoplasmic membrane, and hence the interest in acting on the latter. Quaternary ammoniums are recognized as having excellent antimicrobial power, due to the fact that they are positively charged surfactants. Since the cell membrane is negatively charged, they can be absorbed thereon rapidly and become bound, which will disrupt the cytoplasmic membrane, modify the cell permeability and precipitate the cell constituents, leading to rapid death of the cell even at low doses. Positively charged compounds of high molecular weight thus prove to be worthy of interest (betaines, phosphonium salts, zwitterions, quaternary ammoniums, etc.). Many references exist on the industrial exploitation of quaternary ammoniums. Amine oxides are advantageous compounds since, when placed in acidic solution, they become cationic.
Amine oxides have been the subject of many studies. They are generally biodegradable and prove to be very effective constituents in detergents and shampoos, but also in disinfection. As a reference, mention may be made of the review by S. H. Shapiro, pages 32 to 50, published in the supplement to the 2nd edition of Kirk Othmer's Encyclopaedia of Chemical Technology.
Amine oxides have, to date, been used only as co-surfactants in thickened compositions. Mention may be made for example, in this respect, of the international patent applications published under the numbers WO 96/19558, WO 96/19559 and WO 96/17044 and U.S. Pat. No. 5,078,896.
SUMMARY OF THE INVENTION
The Applicant has now found, unexpectedly, that amine oxides act in synergy with peracetic acid, at concentrations in solution which do not lead to any appreciable thickening of the solution.
The subject of the present invention is thus a composition in the form of an aqueous solution, characterized in that it comprises:
a) from 0.0005% to 20% by weight of peracetic acid,
b) from 0.001% to 45% by weight of acetic acid,
c) from 0.001% to 35% by weight of hydrogen peroxide,
d) from 0.0001% to 2% by weight of at least one compound of formula (I)
(R
1
) (R
2
) (R
3
)N→O (I)
in which, either R
1
represents a linear or branched, cyclic or acyclic radical containing from 1 to 40 carbon atoms and optionally from 1 to 6 hetero atoms chosen from oxygen, sulphur and nitrogen, and R
2
and R
3
, which may be identical or different, represent a linear or branched alkyl radical containing from 1 to 4 carbon atoms or a linear or branched hydroxyalkyl radical containing from 1 to 4 carbon atoms; or R
1
and R
2
represent, together with the nitrogen atom to which they are attached, a saturated or unsaturated, substituted or unsubstituted heterocycle containing from 5 to 8 carbon atoms and from 1 to 4 hetero atoms chosen from oxygen, nitrogen and sulphur, and R
3
represents a linear or branched alkyl radical containing from 1 to 4 carbon atoms or a linear or branched hydroxyalkyl radical containing from 1 to 4 carbon atoms,
e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and characterized in that
f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that
g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2,
provided that the nonionic surfactant which is optionally comprised within said composition is not a compound having the general formula (III):
(R
9
) (R
10
) CH—(O—CH
2
—CH
2
)
n
—OH (III)
in which R
9
and R
10
are each either hydrogen or linear or branched alkyl such that R
9
plus R
10
has a total of from 7 to 22 carbon atoms, and n is selected in the range of 1 to 15, such that the number ratio of carbon atoms in R
9
plus R
10
:n is greater than or equal to 3:1 and provided that the nonionic surfactant is not a dinonyl phenolethoxylate of EO from 4 to 8.
When R
1
represents an acyclic radical, it is in particular a linear or branched alkyl radical; this radical can be unsubstituted, monosubstituted or polysubstituted; when this radical is substituted, the substituent(s) is (are) chosen, independently of each other, from hydroxyl, alkyloxy, alkylthio, carboxyl and alkoxycarbonyl radicals, from halogen atoms or from cycloalkyl or phenyl radicals; when R
1
represents a cyclic radical, it is a mononuclear or polynuclear radical; this radical can be unsubstituted, m
Godin Catherine Hamon
Gouges Yves
Le Rouzic Daniel
Chemoxal SA
Choi Frank
Pak John
Young & Thompson
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