Synergistic composition comprising a fibroblast growth factor an

Details Synergistic composition comprising a fibroblast growth factor an Synergistic composition comprising a fibroblast growth factor an

1992-01-31

1994-02-22

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 514 54, 514 56, 514 59, 514885, 514886, 514889, A61K 3700

Patent

active

052887049

ABSTRACT:
A pharmaceutcial composition is provided for use in the prevention or treatment of viral infections caused by enveloped viruses. The composition comprises a fibroblast growth factor, a sulfated polysaccharide with antiviral activity, and one or more pharmaceutically acceptable carriers. The fibroblast growth factor may be a basic fibroblast growth factor or an analogue thereof, and the polysaccharide may be a carrageenan, heparin, dextran sulfate, pentosan polysulfate or a sulfated polysaccharides produced by marine algae belonging to the class of Rhodophyceae.

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Science, vol. 248, Jun. 15, 1990, pp. 1410-1413, R. J. Kaner, et al., "Fibroblast Growth Factor Receptor is a Portal of Cellular Entry for Herpes Simplex Virus Type 1".
The Lancet, vol. 1, No. 8546, Jun. 13, 1987, p. 1379, R. Ueno, et al., "Dextran Sulphate, a Potent Anti-HIV Agent In Vitro Having Synergism with Zidovudine".
Proceedings of the National Academy of Sciences of U.S.A., vol. 87, No. 18, Sep. 1990, pp. 6985-6989, M. C. Kiefer, et al., "Ligand-Affinity Cloning and Structure of a Cell Surface Heparan Sulfate Proteoglycan That Binds Basic Fibroblast Growth Factor".
Gospodarowicz et al., "Heparin Protects Basic and Acidic FCF . . . ", Jour. of Cellular Physiology, 128:475-484 (1986).

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