Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-02-03
2008-09-02
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S561000, C514S565000, C544S256000, C544S343000, C544S220000, C562S507000, C562S512000, C564S462000, C564S463000
Reexamination Certificate
active
07419981
ABSTRACT:
The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. A particularly preferred PDEV inhibitors is sildenafil.
REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
patent: 6500954 (2002-12-01), Gouliaev et al.
patent: 6500955 (2002-12-01), Chawla et al.
patent: 6500972 (2002-12-01), Cheng et al.
patent: 6579879 (2003-06-01), Mylari
patent: 2004/0157847 (2004-08-01), Field et al.
patent: 0934061 (1997-07-01), None
patent: 1129706 (2000-10-01), None
patent: 641330 (2001-10-01), None
patent: WO0126659 (2001-04-01), None
patent: WO0128978 (2001-04-01), None
patent: WO02085839 (2002-10-01), None
patent: WO03082807 (2003-10-01), None
2006 Chemical Abstracts Service Catalog, published by Chemical Abstracts Service, p. 52.
Avery's Drug Treatment: Principles and Practice of Clinical Pharmacology and Therapeutics, 3rd Edition, 1987, Edited by Trevor M. Speight, Chapter VIII, pp. 255-282.
The Merck Manual of Diagnosis and Therapy, seventeenth edition, 1999, Published by Merck Research Laboratories, pp. 1371-1372.
Jain N, et al, “Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway” Brian Research, 2001, pp. 170-178, vol. 909.
Asomoza-Espinosa R, et al, “Sildenafil increases diclofenac antinociception in the formalin test” Eur. J. Pharm., 2001, pp. 195-200, vol. 418.
Mixcoatl-Zecuatl T, et al, “Seldenafil produces antinociception and increases morphine anitnociception in the formalin test” Eur. J. Pharm., 2000, pp. 81-87 vol. 400.
Field Mark John
Williams Richard Griffith
Benson Gregg C.
Jiang Shaojia Anna
Olson A. Dean
Olson Eric S
Pfizer Inc.
LandOfFree
Synergistic combinations of an alpha-2-delta ligand and a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synergistic combinations of an alpha-2-delta ligand and a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synergistic combinations of an alpha-2-delta ligand and a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3982649