Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-08-11
1998-01-20
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
424 701, 424400, 424401, 514387, 514861, 514864, 514880, 514881, A61K 3119, A61K 31415
Patent
active
057101779
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
The present invention relates to cosmetic and/or dermatological active compound combinations for cosmetic and/or dermatological care of the skin and/or of the integumentary appendages, and to cosmetic and/or dermatological formulations comprising such active compound combinations. The invention furthermore relates to methods for care and regeneration of the skin and/or the integumentary appendages and to the use of cosmetic and/or dermatological active compound combinations for cosmetic and/or dermatological care of the skin and/or of the integumentary appendages.
The integumentary appendages include head and body hair and, in particular, the finger nails and toe nails.
Skin care in the context of the invention is primarily to be understood as meaning that the natural function of the skin as a barrier against environmental influences (for example dirt, foreign substances, micro-organisms) and against the loss of endogenous substances (for example water, electrolytes, natural moisture-binding substances) is intensified, assisted and, if necessary, re-established.
If the natural function of the skin is disturbed, increased absorption of toxic and/or allergenic foreign substances or attack by pathogenic microorganisms and, as a consequence, inflammatory or allergic skin reactions may occur.
The human skin constantly loses a certain amount of moisture by endogenous mechanisms, for example by perspiration. However, the skin also loses important functional constituents through external influences, such as daily washing of the body, wind and weather. Although healthy skin is entirely capable of compensating for this loss, the aim of skin care is to assist the skin in compensating for this loss.
However, if the natural regeneration capacity of the skin is inadequate, for example as a result of severe stress or even an illness, it is essential to assist the endogenous regulation mechanisms for re-establishing the barrier function of the skin by means of external agents which can be applied topically.
The health of nails and their external appearance can be impaired considerably by environmental influences, in particular by solvents in many nail varnish removers, but also by frequent contact with other liquid cleaning agents, for example washing-up liquids, detergents and polishes.
Nail care products should clean finger and toe nails and give them an attractive appearance. Specifically, the aim of nail care is to re-establish and promote a normal functional profile of the toe and finger nails.
Nail varnishes in particular, but also special nail care formulations, often based on cosmetic or dermatological emulsions, are used for nail care.
However, most nail care products of the prior art have proved to be inadequate, since the horny layers of the nails can be penetrated by most nail care products only with difficulty, and usually contain no constituents which adequately assist the skin's own lipid metabolism.
It has been found, surprisingly, and therein lies the achievement of the object, that cosmetic and/or dermatological active compound combinations comprising general formula ##STR1## and/or an active amount of one or more .alpha.-ketocarboxylic acids of the general formula ##STR2## wherein R' and R" in each case independently of one another are chosen from the group consisting of or more carboxyl groups and/or hydroxyl groups and/or aldehyde groups and/or oxo groups (keto groups), hydroxyl groups and/or branched and/or unbranched C.sub.1-25 -alkyl groups, or wherein the .alpha.-carbon atom of the .alpha.-hydroxycarboxylic acid, together with R' and R", forms an or more carboxyl groups and/or hydroxyl groups and/or oxo groups (keto groups) and/or branched and/or unbranched C.sub.1-25 -alkyl groups, acids or the .alpha.-ketocarboxylic acid or the .alpha.-ketocarboxylic acids can optionally be present in the form of their physiologically tolerated salts and/or ethyl esters and/or methyl esters, defects of the prior art. occasionally also called vitamin H (skin vitamin), although it is now counted among
Sauermann Gerhard
Schonrock Uwe
Schreiner Volker
Stab Franz
Beiersdorf AG
Dodson Shelley A.
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