Synergistic combination of t-PA and prostacyclin

Details Synergistic combination of t-PA and prostacyclin Synergistic combination of t-PA and prostacyclin

1987-08-04

1989-06-13

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 9464, 424 9463, 435226, 435212, 514822, 514531, 514573, A61K 37547, A61K 31557

Patent

active

048391697

ABSTRACT:
A combination of t-PA and a prostaglandin of use in removing or inhibiting the formation of a blood clot in a mammal.

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patent: 4539333 (1985-09-01), Moncada
patent: 4632919 (1986-12-01), Spillert et al.
J. Pharmac. Exp. Therap., 222 (3), 544-9, (1982).
Thromb Res, 29, 655-60, (1983).
J Cardiovasc. Pharmac., 7, 739-46, (1985).
Ubatuba et al., Chem Abs, 91: 69052q, 1979.
Schumacher et al., Chem Abs. 103: 98516r, 1985.
Gorog et al., Chem Abs., 106: 13536m, 1986 (pub date).
Marx, Science, 196, Jun. 1977, pp. 1072-1075.
Collen et al., Chem Abs, 98 (15): 119425f, 1983.

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