Synergistic combination of an opioid analgesic and a NSAID

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S396000

Reexamination Certificate

active

07375106

ABSTRACT:
The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given sequentially or simultaneously can be used for the treatment of pain diminishing the side-effects observed in conventional opioid treatments.

REFERENCES:
patent: 5516803 (1996-05-01), Raffa
patent: 5681830 (1997-10-01), Chang et al.
patent: 0 711 289 (1994-07-01), None
patent: 0 649 657 (1995-04-01), None
patent: WO 94 10987 (1994-05-01), None
Picard, P. et al.: “Ketorolac potentiates morphine in postoperative patient-controlled analgesia” Pain (Aug. 1997) V73, p. 401-406, XP-002213157.
Cataldo et al., “Ketorolac and Patient Controlled Analgesia in the Treatment of Postoperative Pain,”Gynecol. Obstet. 176(1993) 435-438.
Cordell et al., “Comparison of Intravenous Ketorolac, Meperidine, and Both (Balanced Analgesia) for Renal Colic,”Ann. Emerg. Med. 28(1996) 151-158.
Ding et al., “Use of Ketorolac and Fentanyl During Outpatient Bynecologic Surgery,”Anesth. Analg. 77(1993) 205-210.
Gupta et al., “Postoperative Pain Following Knee Arthroscopy: The Effects of Intra-articular Ketorolac and/or Morphine,”Reg. Anesth. Pain Med. 24(1999) 225-230.
Joishy et al., “The Opioid-Sparing Effects of Intravenous Ketorolac as an Adjuvant Analgesic in Cancer Pain: Application in Bone Metastases and the Opioid Bowel Syndrome,”J. Pain Symptom Manag. 16(1998) 334-339.
Popp et al., “A Comparison of Ketorolac Tromethamine/Oxycodone Versus Patient-Contolled Analgesia with Morphine in Anterior Cruciate Ligament Reconstruction Patients,”Arthroscopy14 (1998) 816-819.
See et al., “An Outcome Study of Patient-Controlled Morphine Analgesia, With or Without Ketorolac, Following Radical Retropubic Prostatectomy,”J. Urol. 154(1995) 1429-1432.
Sevarino et al., “The Efficacy of Intramuscular Ketorolac in Combination with Intravenous PCA Morphine for Postoperative Pain Relief,”J. Clin. Anesth. 4(1992) 285-288.
Tallarida, et al., “Statistical analysis of drug-drug and site-site interactions with isobolograms,”Life Sci. 45(1989) 947-961.
Tallarida “Statistical analysis of drug combinations for synergism,”Pain 49(1992) 93-97.
Varassi et al., “A Double-Blinded Evaluation of Propacetamol Versus Ketorolac in Combination with Patient-Controlled Analgesia Morphine: Analgesic Efficacy and Tolerability After Gynecologic Surgery,”Anesth. Analg. 88(1999) 611-616.

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