Synergistic antiviral nucleoside combinations

Details Synergistic antiviral nucleoside combinations Synergistic antiviral nucleoside combinations

1994-12-09

1996-11-05

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514 49, 514 50, 514885, 514922, 536 2714, 536 282, A61K 3170

Patent

active

055717985

ABSTRACT:
An antiviral composition comprising in combination an effective antiviral amount of 3'-fluoro-2',3'-dideoxy nucleoside compound I of the formula ##STR1## wherein B is adenine, thymine, guanine, cytosine, inosine, uracil, 5-ethyluracil, 2,6-diaminopurine; and an effective antiviral amount of 2',3'-dideoxy nucleoside compound II of the formula ##STR2## wherein X is N.sub.3 or H or together with Y forms an additional carbon-carbon bond, Y and Z are independently H, OH or F, and B is adenine, thymine, guanine, cytosine, inosine, uracil, 5-ethyluracil, 2,6-diaminopurine, and a physiologically acceptable carrier.

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