Synergistic antiviral compositions

Details Synergistic antiviral compositions Synergistic antiviral compositions

1994-06-02

1997-02-18

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514256, 514269, 514274, 514885, A61K 31505, A61K 3152, A61K 3170

Patent

active

056042094

ABSTRACT:
Antiviral agents which comprises as active ingredients one or more 2',3'-dideoxyribonucleosides or phosphoric esters thereof and 6-benzyl-1-ethoxymethyl-5-substituted uracil derivative of the formula (I): ##STR1## wherein X is oxygen or sulfur atom; R.sup.1 is ethyl or isopropyl; R.sup.2 and R.sup.3 are independently hydrogen atom, C.sub.1 -C.sub.3 alkyl or halogen atom, which compounds can inhibit HIV reverse transcriptase through different mechanisms and are synergistic in combination.

REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 5026687 (1991-06-01), Yarchoan et al.
patent: 5071983 (1991-12-01), Koszalka et al.
patent: 5318972 (1994-06-01), Miyasaka et al.
Molecular Pharmacology, vol. 39, No. 6, 1991, pp. 805-810, M. Baba, et al., "Highly Potent and Selective Inhibition of Human Immunodeficiency Virus Type 1 by a Novel Series of 6-Substituted Acyclouridine Derivatives".
Antimicrobial Agents and Chemotherapy, vol. 35, No. 7, Jul. 1991, pp. 1430-1433, M. Baba, et al., "Synergistic Inhibition of Human Immunodeficiency Virus Type 1 Replication by 5-Ethyl-1-Ethoxymethyl-6-(Phenylthio)Uracil (E-EPU) and Azidothymidine in Vitro".
Antimicrobial Agents and Chemotherapy, vol. 38, No. 4, Apr. 1994, pp. 688-692, M. Baba, et al., "Preclinical Evaluation of MKC-442, A Highly Potent and Specific Inhibitor of Human Immunodeficiency Virus Type 1 in Vitro".
Molecular Pharmacology, vol. 44, No. 4, Oct. 1993, pp. 895-900, S. Yuasa, et al., "Selective and Synergistic Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Non-Nucleoside Inhibitor, MKC-442".
Dialog Information Services, Inc., File 157:AIDSLINE, AN-00023673, S. Yuasa, et al., "Synergistic RT Inhibition of a New HEPT Derivative With AZT.TP," & International Conference on AIDS, Jun. 6-11, 1993, vol. 9, No. 1, p. 479.

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