Synergistic antiphlogistic compositions and methods of use

Details Synergistic antiphlogistic compositions and methods of use Synergistic antiphlogistic compositions and methods of use

1983-03-10

1985-12-03

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514966, 514960, A61K 3160, A61K 31505

Patent

active

045565635

ABSTRACT:
The invention relates to synergistic antiphlogistic pharmaceutical compositions comprising a pyrido [1,2-a]-pyrimidine derivative of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 stands for lower alkoxycarbonyl or carbamoyl and the dotted line represents an optionally hydrogenated band or a salt or quaternary salt thereof and 1-[p-chloro-benzoly]-2-methyl-5-methoxy-indolyl-3-acetic acid of the Formula II ##STR2## The advantage of the compositions is that as a result of the synergistic activity of the compound of the Formula I, the antiphlogistic Indomethacin of the Formula II can be administered in a significantly lower doses and consequently the unfavorable side effects of the latter compound are mitigated.

REFERENCES:
Hippius et al., Zbl. Pharm. 119 (1980), Part 2, pp. 147-157, which is equivalent to Chem. Abstracts (R) of Record.
Farago et al., Zbl. Pharm. 122 (1983), Part 1, 19-21.
Chem. Abst. 92-180h, (1980).
Chem. Abst. 94-52988p, (1981).

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