Synergistic antimicrobial compositions

Drug – bio-affecting and body treating compositions – Plural fermentates of different origin

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A61K 3500

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active

044041896

ABSTRACT:
A synergistic antimicrobial active ingredient for a pharmaceutical or veterinary composition comprises 5 to 50 percent by weight of a primycin component which consists of a primycin fermentation product of Thermonospora galeriensis and 95 to 50 percent by weight of at least one other component selected from the group which consists of doxycyline compounds and sisomicin compounds. The doxycycline compounds are selected from the group which consists of doxycycline, salts thereof with mineral acids, and doxycycline tryclate. The sisomicin compounds are selected from the group which consists of sisomicin, substituted sisomicins with substitution at the N atom by lower alkyl, hydroxyl lower alkyl, lower aminoalkyl and lower alkanoyl, and sisomicin acid salts.

REFERENCES:
patent: 3907771 (1975-09-01), Weinstein et al.
patent: 3949077 (1976-04-01), Buzna et al.

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