Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se – Higher plant – seedling – plant seed – or plant part
Patent
1997-12-19
1999-11-09
Smith, Lynette R. F.
Multicellular living organisms and unmodified parts thereof and
Plant, seedling, plant seed, or plant part, per se
Higher plant, seedling, plant seed, or plant part
800279, 800205, 800250, 4351723, 4353201, 435419, A01H 500, A01H 510
Patent
active
059818441
ABSTRACT:
Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.
REFERENCES:
patent: 4486451 (1984-12-01), Linton et al.
patent: 5559034 (1996-09-01), Roberts et al.
Laue Bridget E.
Potter Sharon L.
Roberts Walden K.
Selitrennikoff Claude P.
Hehman Mary K.
Nelson Amy J.
Novartis Finance Corporation
Smith Lynette R. F.
University Research Corporation
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