Synergistic antibacterial compositions and method of treatment o

Details Synergistic antibacterial compositions and method of treatment o Synergistic antibacterial compositions and method of treatment o

1981-12-21

1984-06-05

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

A61K 3500

Patent

active

044527780

ABSTRACT:
Antibiotic compositions comprising a 1-oxa .beta.-lactam antibiotic compound of the formula ##STR1## or pharmaceutically acceptable salts thereof and either tobramycin, amikacin or piperacillin exhibit synergistic activity against multiple-antibiotic-resistant organisms. The 1-oxa compound can be used in conjunction with tobramycin, amikacin or piperacillin in a method of treating infections caused by resistant organisms.

REFERENCES:
patent: 4138486 (1979-02-01), Narisada et al.
Physician Desk Reference (1979), pp. 1043-1045.
Evans et al., J. of Antimicrobial Chemotherapy (1978) 4, pp. 255-261.
Tjandramaga et al., Antimicrobial Agents & Chemotherapy (1978) 14, pp. 829-837.
Chanbasavakam et al., Antimicrobial Agents & Chemotherapy (1978) 14, pp. 505-506.
Lin et al., J. of Antimicrobial Chemotherapy (1979) 5, pp. 37-44.
Farrell et al., J. of Antimicrobial Chemotherapy (1979) 5, pp. 23-29.
Basker et al., J. of Antimicrobial Chemotherapy (1977) 3, pp. 273-282.
Anoviole, J. of Infectious Diseases (1974) 129, pp. 124-133.

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