Synephrine derivatives useful as anti-inflammatory agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S548000, C548S334100, C560S130000

Reexamination Certificate

active

08039501

ABSTRACT:
This invention provides compounds having the structural formula:wherein:R1is an acyl or sulfonyl group,R2is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monocarboxylic acids, imidazolylcarbonyl and triazolylcarbonyl, andR3is hydrogen or an amino-protecting group,a stereoisomer thereof, a solvate thereof, or a salt thereof, being useful as anti-inflammatory agents and anti-cancer agents.

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Byrn et al., Chapter 11 Hydrates and Solvates in Solid-State Chemistry of Drugs (2nd Ed.), 1999, 233-247, 233.
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A.M. Rouhi, Chem. & Eng. News, Feb. 24, 2003, 81(8), 32-35.
International Preliminary Report on Patentability for International Patent Application No. PCT/EP2006/012520, mailed Jul. 3, 2008.
Ibrahim et al., “Quantitative Measurement of Octopamines and Synephrines in Urine Using Caprillary Column Gas Chromatography Negative Ion Chemical Ionization Mass Spectrometry,”Analytical Chemistry, vol. 56: 1695-1699, 1984.
International Search Report and Written opinion of the International Searching Authority (PCT/EP2006/012520) mailed Mar. 29, 2007.
European Patent Office Communication (EP 06841157.8) dated Jun. 23, 2011.

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