Syndonimine derivatives, process for production thereof, and use

Details Syndonimine derivatives, process for production thereof, and use Syndonimine derivatives, process for production thereof, and use

1982-07-29

1983-12-20

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544367, 544382, 548125, C07D41304, A61K 31495

Patent

active

044217544

ABSTRACT:
A 3-[4-(benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents zero or an integer of 1 to 10,
and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 4-(benzoylalkyl)-1-(N-nitrosocyanomethylamino)piperazine represented by the following formula ##STR2## wherein R and n are as defined, with an acid.

REFERENCES:
patent: 3812128 (1974-05-01), Masuda
patent: 3833589 (1974-09-01), Simpson
Chem. Pharm. Bull. 18 (1) 128-132, (1970) "Studies on Mesoionic Compounds, I, Synthesis of 3-Dialkylaminosydnonimines" Masuda, et al.
Oyo Yakuri (Applied Pharmacology) 2 (3) 280-287, (1968) "The Synthesis of Mesoionic and Related Compounds", Masuda et al.

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