Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-07-15
2008-07-15
Allen, Marianne P (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07399830
ABSTRACT:
Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.
REFERENCES:
patent: 5767252 (1998-06-01), Worley et al.
Marra et al., Accession No. AA212542, Feb. 14, 1997. Alignment with SEQ ID No:1, 1997.
GenBank Accession No. AA212542 (Feb. 19, 1997).
Database EMBL, Aug. 1, 1997 “Rattus norvegicusmRNA for Vesl, complete cds” XP002289065—Accession No. AB003726 *Abstract.
Kato et al., “vesl, a gene encoding VASP/Ena family related protein, is unregulated during seizure, long-term potentiation and synaptogenesis”, FEBS Letters. Jul. 21, 1997, vol. 412, No. 1, Jul. 21, 1997, pp. 183-189.
Database EMBL, Nov. 15, 1997, “Rattus norvegicusactivity and neurotransmitter-induced early gene 3 (ania-3) mRNA, 3'UTR.” XP002289066—Accession No. AF03008 *Abstract.
Goodman, et al. “Long Pentraxins: an Emerging Group of Proteins with Diverse Functions,”Cytokine&Growth Factor Reviews, 7(2);191-202 (1996).
Hsu and Perin, “Human Neuronal Pentraxin II (NPTX2): Conservation, Genomic Structure, and Chromosomal Localization,”Genomics, 28:220-227 (1995).
Noland, et al., “The Sperm Acrosomal Matrix Contains a Novel Member of the Pentaxin Family of Calcium-Dependent Binding Proteins,”J Biol Chem, 269(51):32607-32614 (1994).
Omeis, et al., “Mouse and Human Neuronal Pentraxin 1 (NPTX1): Conservation, Genomic Structure, and Chromosomal Localization,”Genomics, 36:543-545 (1996).
Reid and Blobel, “Apexin, an Acrosomal Pentaxin,”J Biol Chem, 269(51):32615-32620 (1994).
Rudinger, J., “Characteristics of the Amino Acids as Components of a Peptide Hormone Sequence,”Peptide Hormones, ed. J.A. Parsons, University Park Press, Baltimore, pp. 1-7 (1976).
Tsui, et al., “Narp, a Novel Member of the Pentraxin Family, Promotes Neurite Outgrowth and Is Dynamically Regulated by Neuronal Activity,”J of Neuroscience, 16(8):2463-2478 (1996).
Tsui, et al., “Narp, a Novel Member of the Pentraxin Family, Promotes Neurite Outgrowth and Is Dynamically Regulated by Neuronal Activity,”Molecular Biology of the Cell, 6:214A (1995).
Tsui, et al., “Narp, a Novel Member of the Pentraxin Family of Proteins that is Synthesized, Secreted and Active as a Monomeric Molecule,”Society for Neuroscience Abstracts, 22:299 (1996).
Brakeman Paul R.
Worley Paul F.
Allen Marianne P
DLA Piper (US) LLP
Johns Hopkins University
LandOfFree
Synaptic activation protein compositions and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synaptic activation protein compositions and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synaptic activation protein compositions and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2794493