Syn isomers of cephalosporins having .alpha.-hydroximino- or .al

Details Syn isomers of cephalosporins having .alpha.-hydroximino- or .al Syn isomers of cephalosporins having .alpha.-hydroximino- or .al

1975-02-28

1977-05-17

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50120

Patent

active

040241343

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3898219 (1975-08-01), Breuer et al.

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