Syn isomers of cephalosporins having .alpha.-hydroximino- or .al

Details Syn isomers of cephalosporins having .alpha.-hydroximino- or .al Syn isomers of cephalosporins having .alpha.-hydroximino- or .al

1978-10-16

1980-06-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 30, 424246, C07D50120

Patent

active

042096162

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3546219 (1970-12-01), Long et al.
patent: 3573294 (1971-03-01), Long et al.
patent: 4024133 (1977-05-01), Cook et al.
patent: 4024134 (1977-05-01), Gregson et al.

Affiliated with

Also associated with

Rating

Syn isomers of cephalosporins having .alpha.-hydroximino- or .al does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Syn isomers of cephalosporins having .alpha.-hydroximino- or .al, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Syn isomers of cephalosporins having .alpha.-hydroximino- or .al will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1481397