Sympathomimetic topical and percutaneous administration with hal

Details Sympathomimetic topical and percutaneous administration with hal Sympathomimetic topical and percutaneous administration with hal

1975-05-01

1976-07-06

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424343, A61K 31135, A61K 31045, A61K 4700

Patent

active

039682455

ABSTRACT:
Dermal compositions are disclosed with comprise trichloroethanol or trifluoroethanol as one component of a vehicle having solubilized therein a drug or other beneficial chemical compound. Also disclosed is a method for administering a drug or other beneficial chemical compound to the body which comprises contacting the skin with the drug or compound in the presence of trichloroethanol or trifluoroethanol which acts as an absorption promoter to enhance the topical or percutaneous absorption of the active drug or compound.

REFERENCES:
patent: 3787571 (1974-01-01), Higuchi
patent: 3891757 (1975-06-01), Higuchi
Lehman et al. J. Pharmacol. 63:453-465 (1938) "Trichloroethanol, Tribromoethanol Chloral Hydrate and Bromal Hydrate."
Hewer et al. Lancet 235:129-1291 (1938) "Trichloroethanol as Basal Marcotic."
Case Anesthesiology 41:523-527 (1943) "The Present Status of Trichloroethanol."

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