Sydnonimine N-acyl derivatives and method for preparing same

Details Sydnonimine N-acyl derivatives and method for preparing same Sydnonimine N-acyl derivatives and method for preparing same

1977-11-28

1981-01-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424272, A61K 3142, C07D27104

Patent

active

042451000

ABSTRACT:
N-acyl sydnonimines of the formula: ##STR1## wherein R is phenyl, .beta.-phenylethyl, dl-.alpha.-methyl-.beta.-phenylethyl or l-.alpha.-methyl-.beta.-phenylethyl; R' is hydrogen, phenyl; X is a lower alkyl, phenyl, ##STR2## wherein R" is hydrogen, a halogen, a lower fluorinated alkyl; R'" is hydrogen, a halogen, a lower alkyl; when R is dl-.alpha.-methyl-.beta.-phenylethyl, R' is H, R" is Cl, R'" is only Cl, while when R' is H, X is NHC.sub.6 H.sub.5 R is only l-.alpha.-methyl-.beta.-phenylethyl; when X is phenyl, R and R' are each phenyl only.
The method for preparing sydnonimine N-acylderivatives comprises reacting N-nitrosoderivatives of N-substituted nitriles of .alpha.-aminoacids of the formula: ##STR3## wherein R is phenyl, .beta.-phenylethyl, di-.alpha.-methyl-.beta.-phenylethyl or l-.alpha.-methyl-.beta.-phenylethyl; R' is H, phenyl; when R' is phenyl R is phenyl only, with an acylation agent in a solvent medium in the presence of a basic-character catalyst, followed by isolation of the desired product.

REFERENCES:
patent: 3277108 (1966-10-01), Daeniker
patent: 3833580 (1974-09-01), Gotz

Affiliated with

Also associated with

Rating

Sydnonimine N-acyl derivatives and method for preparing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sydnonimine N-acyl derivatives and method for preparing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sydnonimine N-acyl derivatives and method for preparing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2232537