Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1995-10-12
1999-06-01
Minnifield, Nita
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4242561, 4242571, 4242581, 4242341, 4242361, 424825, 4242411, 514 2, A61K 39102, A61K 3902, A61K 39205, A01N 3718
Patent
active
059086300
ABSTRACT:
An improved method and vaccine is provided for the immunization of swine against infectious diseases caused by RTX toxin-secreting bacteria (e.g., porcine pleuropneumonia) which comprises administering to swine an effective amount of a live, immunizing, RTX toxin-secreting organism which induces in the swine a sufficiently high RTX toxin-neutralizing antibody titer to at least prevent clinical symptoms of the disease in the swine. For example, an intranasally administered, live, low virulence strain of A. suis (EM1) confers immunity upon swine against challenge with a virulent, disease-causing strain of A. pleuropneunmoniae.
REFERENCES:
patent: 3364117 (1968-01-01), Smith
patent: 3907987 (1975-09-01), Wilson
patent: 3975517 (1976-08-01), Wilson
patent: 4559306 (1985-12-01), Kucera
patent: 4626430 (1986-12-01), Kucera
patent: 4681762 (1987-07-01), Oeschger et al.
patent: 5525504 (1996-06-01), Goebel et al.
patent: 5559008 (1996-09-01), Chang
patent: 5726016 (1998-03-01), De Muth et al.
Pohl et al International J. Systematic Bacteriology 33:510-514, 1983.
Conlon et al, Inf. & Imm. 59(2):587-591, 1991.
Macinnes et al Ed:Gylesetal IN: Pathogenesis of Bacterial Infections In Animals.
Menestrina et al, Toxicology, 87:249-267, 1994.
Welch, Mol. Microbiology, 5 (3):521-528, 1991.
Nielsen, Nord. Vet. Med. 86: 221-234, 1984.
Czuprynski et al. 1995. Trends in Microbiol. 3(12):480-83.
Lally et al. 1994. JBC. 269(49): 31289-31295.
Jansen et al. 1995. Inf. & Imm. 63(1):27-37.
Chang et al. 1993 Inf & Imm. 61(5): 2089-95.
Forestier et al. 1991. Inf & Imm. 59(11): 4212-4220.
Tarigan et al. 1996. Australian Vet. J. 73(5):164-169.
Guthmiller et al. 1995. Microbial Pathogenesis. 18:307-321.
Kobisch et al. 1989. Vet. Rec. 124:57-61.
Ma 1991. Dissabs. Int. 52(12B):6213.
Fogrd et al. 1989. Vet. Rec. 125:7-11.
Bosse et al. 1992. Inf. & Imm. 60(2): 479-84.
Frey et al. 1993 J. Gen. Microbiol. 139:1723-28.
Fenwick et al. 1986. Inf. & Imm. 54(2): 575-82.
Lenser et al. 1988. Vet. Microbiol. 18:335-48.
Coote, Structural and Functional Relationships Among the RTX Toxin Determinants of Gram-Negative Bacteria; FEMS Microbiology Reviews 88 (1992) 137-162.
Welch, et al. The Synthesis and Function of the Escherichia coli Hemolysin and Related RTX Exotoxins; FEMS Microbiology Immunoloogy 105 (1992) 29-36).
Taylor, Actinobacillus equuli and A. suis, Section 4, Bacterial Diseases, pp. 634-636, 1986.
Hennessy, et al.; Serotype Identification of Actinobacillus pleuropneumoniae by Arbitrarily Primed Polymerase Chain Reaction; Journal of Clinical Microbiology, May 1993, pp. 1155-1159. vol. 31, No. 5.
Burrows et al.; Molecular Characterization of an RTX Toxin Determinant from Actinobacillus suis, Infection and Immunity, Jun. 1992, pp. 2166-2173, vol. 60, No. 6.
Frey et al.; Immunological Properties of Actinobacillus pleuropneumoniae Hemolysin I, Veterinary Microbiology, 28 (1991) 61-73.
Devenish et al.; Immunoserological Comparison of 104-Kilodalton Proteins Associated with Hemolysis and Cytolysis in Actinobacillus pleuropneumoniae, Actinobacillus suis, Pasteurella haemolytica, and Escherichia coli, Infection and Immunity, Oct. 1989, pp. 3210-3213, vol. 57, No. 10.
Kansas State University Research Foundation
Minnifield Nita
LandOfFree
Swine immunization using live, RTX toxin-secreting organisms does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Swine immunization using live, RTX toxin-secreting organisms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Swine immunization using live, RTX toxin-secreting organisms will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-953575