Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1988-09-14
1992-05-05
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
42 88, 530350, 530395, A61K 3902, A61K 3514
Patent
active
051105896
ABSTRACT:
The present invention relates to a method for the preparation of a swine dysentary subunit vaccine. The swine dysentery subunit vaccine is composed of antigenic material harvested from the surface of an anaerobic spriochete, Treponema hyodysenteriae. The bacterial cells, previously grown in large volume (5-7 liters) in a bench-top fermentor, are harvested by centrifugation and washed vigorously in phosphate buffered saline. The bacterial cells are then removed by a second centrifugation and the supernatant retained. The supernatant contains a salt extract consisting of the antigenic material used in the vaccine. Once harvested, the salt extract is concentrated 100X. The salt extract has been shown to be immunogenic in pigs. Five to six week old pigs are hyperimmunized intramuscularly (IM) with the salt extract. Pigs vaccinated with the salt extract are protected against infection with Treponema hyodysenteriae.
REFERENCES:
patent: 4152413 (1979-05-01), Goodnow
patent: 4152415 (1979-05-01), Harris et al.
patent: 4758517 (1988-07-01), Parizek
Kinyon et al., "Growth of Treponema hyodysenteriae in liquid medium" The Veterinary Record, vol. 95, pp. 219-220, 1974.
Joens et al., Infection and Immunity, vol. 54, No. 3, pp. 893-896, Dec. 1986.
Hubbard et al., Conference of Research Workers in Animal Diseases, Reference #300, Nov. 1986.
Miller et al., Conference of Research Workers in Animal Diseases, Reference #D-151 Nov. 1986.
Cramer James D.
Joens Lynn A.
Mapother Mary E.
Arizona Technology Development Corporation
Mohamed Abdel A.
Moskowitz Margaret
Rosenbaum David G.
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