1988-02-19
1989-10-24
Apley, Richard J.
Surgery
Truss
Pad
525205, 525421, 525937, 424426, 424428, F24C 1516
Patent
active
048754790
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to the art of medical engineering and, more particularly, to a suture material.
PRIOR ART
Known in the art are non-resorbing suture material possessing antimicrobal activity, e.g. those based on polyethylene terephthalate or polypropylene with an antimicrobal preparation geomycin fixed thereon by means of a chemical bond. These suture materials ensure retention of soft tissues and the antimicrobal effect for two days (A. A. Shalimov et al., Polymers in Medicine, 1977, vol. VII, No. 1, pp. 19-26). However, threads from such a suture material are not biodegradable and the duration of their antimicrobal effect is rather limited.
Known in the art are suture materials based on a bioresorbing polymer, e.g. hydroxycellulose fibres containing sulphanylamide preparations attached to the base by means of covalent bonds. As the sulphanylamide preparations this material contains, for example, 2-(para-aminobenzosulphamido)-5-ethyl-1,3,4-thiadiazole or O-3-amino-3-desoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[6-amino-6-deso xy-.alpha.-D glucopyranozyl-(1.fwdarw.4)]2-desoxy-D-streptomycin (kanamycin) (USSR Inventor's Certificate No. 338525, Int. Cl. C 08 b 15/02 1968). Threads from this material can undergo biodestruction under the effect of the organism fluids and ensure the antimicrobal effect for 16 days. However, such threads do not posess a sufficient tenacity and the amount of antibacterial agents capable of chemically being attached to the main chain of the suture material is very limited. Furthermore, during the chemical addition the molecule of the antimicrobal preparation is subjected to the effect of chemical reagents which can cause its partial destruction, wherefore the antimicrobal effect is either diminished or fully disappears.
DISCLOSURE OF THE INVENTION
The present invention is directed to the provision, by way of modification of the base, of a suture material exhibiting a high tenacity, incorporating any kinds of antimicrobal preparations and ensuring a broad interval of duration of the antimicrobal effect.
This object is accomplished by that the suture material according to the present invention comprising a base of a bioresolvable polymer and an antimicrobal preparation, according to the present invention contains a layer of a copolymer of N-vinylpyrrolidone with an alkylacrylate and/or an alkylmethacrylate deposited onto the base and containing an antimicrobal preparation or a mixture of preparations. The copolymer layer being biodegradable in a shorter length of time than the base. The layer thickness being equal to 0.1 to 1.0 of the base thickness.
The suture material contains an antimicrobal preparation or a mixture of preparations preferably in an amount of 1 to 40% by weight of the applied layer. The suture material according to the present invention has a number of advantages as compared to the known material, namely:
the suture material according to the present invention has a tensile strength higher by 15-20% than that of the known material;
tenacity of the knot joint of the thread is 25-30% higher than that of the known material;
the material according to the present invention makes it possible to use any kind of antimicrobal preparations including such preparations sensitive to all effects as quinoxaline derivatives;
it enables adjustment of duration of the antimicrobal effect in the injury zone within a wide time interval (from 3 to 20 days).
BEST MODE FOR CARRYING OUT THE INVENTION
The suture material according to the present invention contains a layer of a copolymer of N-vinylpyrrolidone with an alkylacrylate and/or alkylmethacrylate deposited on the base and contains an antimicrobal preparation or a mixture of antimicrobal preparations.
As the antimicrobal preparations useful in the present invention can be any preparation such as antibiotics, sulphanylamide preparations, quinoxaline derivatives, nitrofuran derivatives, hydroxyquinoline derivatives and the like.
The layer deposited onto the base biodestructs in a shorter
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Belykh Sergei I.
Davydov Anatoly B.
Kanshin Nikolai N.
Kirillov Jury B.
Kovalenko Igor L.
Apley Richard J.
Paul N.
Vsesojuzny Nauchno-Issledovatelsky I Ispytatelny Institut Medits
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