Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1986-09-22
1990-05-22
Welsh, J. David
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424 78, 604307, 252308, A61L 1503
Patent
active
049276875
ABSTRACT:
A transdermal drug delivery system useful for the controlled, for example zero order release of one or more drugs to a selected skin area of a user, which system comprises an impervious backing sheet and a face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles generally uniformly dispersed and suspended in the liquid base material. The microparticles containing an effective therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid. In use the liquid base material exuded from the macroporous membrane face forms a thermodynamically stable thin film layer in an intimate contact with the skin, while the drug is released from the microparticles into the base material and transdermally into the user.
REFERENCES:
patent: 3946106 (1976-03-01), Chien et al.
patent: 3992518 (1976-11-01), Chien et al.
patent: 4291015 (1981-09-01), Keith et al.
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4405616 (1983-09-01), Rajadmyaksha
patent: 4463953 (1984-08-01), Keith et al.
patent: 4624665 (1986-11-01), Nuwayser
patent: 4637930 (1987-01-01), Kono et al.
patent: 4638043 (1987-01-01), Szycher et al.
Biotek, Inc.
Welsh J. David
LandOfFree
Sustained release transdermal drug delivery composition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained release transdermal drug delivery composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release transdermal drug delivery composition will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2133887