Sustained release therapeutic compositions based on high molecul

Details Sustained release therapeutic compositions based on high molecul Sustained release therapeutic compositions based on high molecul

1982-03-26

1983-06-21

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 22, 424 35, 424362, A61K 922, A61K 926

Patent

active

043893937

ABSTRACT:
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.

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patent: 4259314 (1981-03-01), Lowey
patent: 4265875 (1981-05-01), Byrne et al.
patent: 4292299 (1981-09-01), Suzuki et al.

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