Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Reexamination Certificate
2006-05-09
2006-05-09
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
C424S464000, C514S964000
Reexamination Certificate
active
07041317
ABSTRACT:
A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.
REFERENCES:
patent: 5075308 (1991-12-01), Ishikawa et al.
patent: 62-51672 (1987-03-01), None
patent: 8-73345 (1996-03-01), None
patent: WO 88/07369 (1988-10-01), None
patent: WO 90/14077 (1990-11-01), None
Hiroshi Azuma et al., “α1-Adrenoceptor antagonist activity of novel pyrimidine derivatives (SH1437 and IK29) in rabbit aorta and trigone of the bladder” (1989) British Journal of Pharmacology 1989 United Kingdom vol. 96, No. 4, pp. 1000-1006.
Supplementary European Search Report dated Jul. 19,2005.
Azuma Hiroshi
Ii Yoshinori
Ishikawa Masayuki
Sekiya Noboru
Fitzgerald Marc C.
Ono Pharmaceutical Co. Ltd.
Page Thurman K.
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