Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1997-10-31
2000-09-05
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424451, 424452, 424423, 424425, 424486, 424489, 514963, 514965, A61K 950, A61K 952, A61K 914
Patent
active
061139432
ABSTRACT:
Disclosed is a sustained-release preparation comprising 1) a polymer of lactic acid having a weight-average molecular weight of about 25,000 to about 60,000 and 2) a physiologically active substance, and which releases the physiologically active substance over a period of at least about 5 months; the sustained-release preparation shows an almost continuous zero order release of the physiologically active substance over a period of as long as about 5 months.
REFERENCES:
patent: 3773919 (1973-11-01), Boswell et al.
patent: 5476663 (1995-12-01), Okada et al.
patent: 5631020 (1997-05-01), Okada et al.
patent: 5631021 (1997-05-01), Okada et al.
Y. Aso et al., "Effect of Temperature on Mechanisms of Drug Release and Matrix Degradation of Poly(D,L-lactide) Microspheres", Journal of Controlled Release, vol. 31, pp. 33-39, 1994.
Y. Tabata et al., "A Formulation Method Using D,L-lactic Acid Oligomer for Protein Release with Reduced Initial Burst", Journal of Controlled Release, vol. 23, pp. 55-64, 1993.
Douken Yayoi
Okada Hiroaki
Page Thurman K.
Seidleck Brian K.
Takeda Chemical Industries Ltd.
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