Sustained-release preparation

Details Sustained-release preparation Sustained-release preparation

1996-04-22

2000-07-11

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424499, 514 3, 514 12, 530399, A61K 2818

Patent

active

060873248

ABSTRACT:
According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity.
According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.

REFERENCES:
patent: 4853218 (1989-08-01), Yim et al.
patent: 5114918 (1992-05-01), Ishikawa et al.
patent: 5192741 (1993-03-01), Orsolini et al.
patent: 5270313 (1993-12-01), Burri et al.
patent: 5271945 (1993-12-01), Yoshioka et al.
patent: 5284828 (1994-02-01), Hemmi et al.
patent: 5292740 (1994-03-01), Burri et al.
patent: 5445832 (1995-08-01), Orsolini et al.
patent: 5510331 (1996-04-01), Hamon et al.
patent: 5643607 (1997-07-01), Okada et al.
patent: 5654010 (1997-08-01), Johnson et al.
patent: 5711968 (1998-01-01), Tracy et al.
Patent Abstract of JP 4-288099.
Lam et al., "Cochinmicins, Novel and Potent Cyclodepsipeptide Endothelin Antagonists from A Microbisphora sp. I. Production, Isolation and Characterization", The Journal of Antibiotics, vol. 45, No. 11, pp. 1709-1716, May 1992.
Zink et al., "Cochinmicins, Novel and Potent Cyclodepsipeptide Endothelin Antagonists from A Microbispora sp. II. Structure Determination", The Journal of Antibiotics, vol. 45, No. 11, pp. 1717-1722, May 1992.
U.S. Patent application No. 071 984,323of Henry Auer, et al., Controlled Released Growth Hormone Containing Microspheres, Filed Dec. 2, 1992.

Affiliated with

Also associated with

Rating

Sustained-release preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sustained-release preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained-release preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-542403