Sustained-release preparation

Details Sustained-release preparation Sustained-release preparation

1993-12-07

1996-01-02

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

525415, 528354, 424 7808, 424 7833, A61K 3800, C08G 6391, C08G 6308, C08L 6700

Patent

active

054808685

ABSTRACT:
A sustained-release preparation which comprises a physiologically active peptide of general formula ##STR1## wherein X represents an acyl group; R.sub.1, R.sub.2 and R.sub.4 each represents an aromatic cyclic group; R.sub.3 represents a D-amino acid residue or a group of the formula ##STR2## wherein R.sub.3 ' is a heterocyclic group; R.sub.5 represents a group of the formula --(CH.sub.2).sub.n --R.sub.5 ' wherein n is 2 or 3, and R.sub.5 ' is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group;

REFERENCES:
patent: 3773919 (1973-11-01), Boswell et al.
patent: 4341767 (1982-07-01), Nestor et al.
patent: 5036047 (1991-07-01), Mai
patent: 5110904 (1992-05-01), Haviv et al.
patent: 5140009 (1992-08-01), Haviv et al.
patent: 5171835 (1992-12-01), Janaky et al.
patent: 5187150 (1993-02-01), Spenser et al.
Hutchinson et al., Trends in Biotich vol. 5(4) p. 102 (1987).

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