Sustained-release prepararation of basic medical agent hydrochlo

Details Sustained-release prepararation of basic medical agent hydrochlo Sustained-release prepararation of basic medical agent hydrochlo

1990-10-26

1993-08-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, 424469, 424480, 424489, 424495, 424497, A61K 964

Patent

active

052346919

ABSTRACT:
A preparation obtained by coating granules containing both a basic medical agent hydrochloride (e.g. allotinolol hydrochloride) and a polyanion the particles of which are present in the form of a discontinuous layer, with a film containing a slightly water-soluble substance, can release said agent at a controlled rate without influenced by the physiological factors of the gastrointestinal tract of a patient when orally administered.

REFERENCES:
patent: 3458622 (1969-07-01), Hill
patent: 4138475 (1979-02-01), McAinsh et al.
patent: 4449983 (1984-05-01), Cortese et al.
patent: 4777033 (1988-10-01), Ikura et al.
patent: 4798725 (1989-01-01), Patel
patent: 4904649 (1990-02-01), Schwartz
European Patent, Abstract, 322-277-A.
Japanese Patent, Abstract 2193-914-A.
European Patent Search 90 31 1748; Jun. 11, 1991; Amat A. Ventura, The Hague.
Patent Abstracts of Japan, vol. 14, No. 470, Oct. 15, 1990, p. 98 C 769 JPA 2193914.

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