Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1989-05-22
1991-01-08
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424458, 424494, 424490, 424497, A61K 924, A61K 916, A61K 950, A61K 954
Patent
active
049834010
ABSTRACT:
A sustained-release pharmaceutical preparation utilizing a pH controlled diffusion membrane composed of a pH sensitive film-forming polymer. The film forming polymer may be an enteric polymer containing phthalic acid with one carboxyl group attached to the enteric polymer via an ester bond, and the second carboxyl group remaining a free acid so that the modified film forming polymer is hydrophobic at low pH and hydrophilic at higher pH. Hydrophobic stearyl side chains are attached to the enteric polymer which causes the pH controlled diffusion membrane to remain insoluble at high pH. Alternatively, the pH sensitive film forming polymer may be a polymer containing hydrophobic and free acid groups so that the modified film forming polymer is hydrophobic at low pH and hydrophilic but insoluble at high pH. In the preferred sustained-release pharmaceutical preparation the film forming polymer is coated into core drug particles to produce a pH controlled diffusion membrane surrounding the core drug and form microparticles which may be admixed with free drug or time-release drug and placed in a gelatin capsule or tabletted.
REFERENCES:
patent: 3155590 (1964-11-01), Miller et al.
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3488418 (1970-02-01), Holliday et al.
patent: 3492397 (1970-01-01), Peters et al.
patent: 3531418 (1970-09-01), Fanger et al.
patent: 3878276 (1975-04-01), Hoernschemeyer
patent: 4025613 (1977-05-01), Guy et al.
patent: 4083949 (1978-04-01), Benedikt
patent: 4205060 (1980-05-01), Monsimer et al.
patent: 4305823 (1981-12-01), Batzer et al.
patent: 4377481 (1983-03-01), Jakabhazy
patent: 4663050 (1987-05-01), Li et al.
Eichel Herman J.
Massmann Brent D.
Cashion Jr. Merrell C.
Kinaform Technology, Inc.
Kishore G. S.
LandOfFree
Sustained release pharmaceutical preparations having pH controll does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained release pharmaceutical preparations having pH controll, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release pharmaceutical preparations having pH controll will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-933363