Sustained release pharmaceutical preparation and process for pre

Details Sustained release pharmaceutical preparation and process for pre Sustained release pharmaceutical preparation and process for pre

1993-08-31

1995-02-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424498, A61K 916

Patent

active

053893808

ABSTRACT:
A sustained release pharmaceutical preparation comprising a carrier, an effective ingredient layer containing a medicinal compound and a heat-meltable material as a binder which is formed around said carrier and a coating layer containing a non-heat-meltable dissolution-controlling agent and a heat-meltable material as a binder which is formed around said effective ingredient layer and the process for preparing the same. According to the present invention, the formation of the effective ingredient layer and the formation of the coating layer can be successively carried out in the same apparatus without using any solvents or drying step in short hours to give a sustained release pharmaceutical preparation which can release a medicinal compound at a suitable dissolution rate according to the physical property of the medicinal compound.

REFERENCES:
patent: 4443428 (1984-04-01), Oshlack
patent: 4684516 (1987-08-01), Bhutani
patent: 4720387 (1988-01-01), Sakamoto
patent: 4834985 (1989-05-01), Elger
patent: 5068112 (1991-11-01), Samejima
Chem. Abstr., vol. 105, 1986, pp. 383, 105:178467g "Coatings for Sustained . . . " Sasagawa, et al.

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