Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1989-04-03
1991-06-25
Page, Thurman
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424474, 424475, 424480, 424490, A61K 954
Patent
active
050265598
ABSTRACT:
A sustained-release pharmaceutical preparation comprising an admixture of uncoated and/or single walled coated drug, and multi-units of microparticles of a multi-walled coated drug. The microparticle structure preferably has a core drug, an inner wall microencapsular enteric coating, such as a polymethyacrylic acid/acrylic acid copolymer or cellulose acetate phthalate, a solid acid such as citric acid, adipic acid, or an acidic ion exchange resin layered onto or included in the enteric layer, and an outer wall microencapsulated control coating, such as a polymethacrylic acid ester copolymer or ethyl cellulose. The multi-walled coated drug has a delayed, gradual, long-term release which takes place in the intestines while the uncoated and/or single walled coated drug has immediate therapeutic properties upon dissolution in the stomach. The enteric coating and control coating may be applied to core drug granules by a coacervation, spray coating or other process. The acid may be a separate layer applied by a spray coating or other process.
REFERENCES:
patent: 3115441 (1963-12-01), Hermelin
patent: 3155590 (1964-11-01), Miller et al.
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3488418 (1970-01-01), Holliday et al.
patent: 3492397 (1970-01-01), Peters et al.
patent: 3531418 (1970-09-01), Fanger et al.
patent: 4025613 (1977-05-01), Guy et al.
patent: 4520009 (1985-05-01), Dunn
patent: 4572833 (1986-02-01), Pederson et al.
patent: 4728512 (1988-03-01), Mehta et al.
patent: 4752470 (1988-06-01), Mehta
patent: 4808413 (1989-02-01), Joshi et al.
Lehmann et al., Practical Course in Lacquer Coating, Rohm Pharma.
Eichel Herman J.
Massmann Brent D.
Horne Leon R.
Kinaform Technology, Inc.
Page Thurman
LandOfFree
Sustained-release pharmaceutical preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained-release pharmaceutical preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained-release pharmaceutical preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1038972