Sustained-release pharmaceutical preparation

Details Sustained-release pharmaceutical preparation Sustained-release pharmaceutical preparation

1990-08-27

1993-08-24

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424463, 424494, 424495, 42840224, 514963, A61K 962, B01J 1322

Patent

active

052386864

ABSTRACT:
A sustained-release pharmaceutical preparation comprising an admixture of uncoated and/or single walled water soluble drug, such as aspirin, and dual walled coated drug. The dual wall structure has an inner wall microencapsular control coating, such as ethyl cellulose, and an outer wall enteric coating such as cellulose acetate phthalate. The dual walled coated drug has a delayed, gradual, long-term release which takes place in the intestines while the uncoated and/or single walled drug has immediate therapeutic properties upon dissolution in the stomach. The outer wall enteric coating may be applied to microencapsulated core drug by a coacervation, spray coating or other process.

REFERENCES:
patent: 3242051 (1966-03-01), Hiestand et al.
patent: 3882228 (1975-05-01), Boncey et al.
patent: 4443497 (1984-04-01), Samejima et al.
patent: 4780318 (1988-10-01), Appelgren et al.

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