Sustained release pharmaceutical formulation

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 35, A61K 950

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active

043168841

ABSTRACT:
It has been found that indoprofen can be used in increased safety at its effective anti-inflammatory dose in humans and that the activity of indoprofen is greatly prolonged by microencapsulating microparticles of indoprofen in a solid protective coating of a cellulose ether such as ethylcellulose.

REFERENCES:
patent: 3155590 (1964-11-01), Miller et al.
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3488418 (1970-01-01), Holliday et al.
patent: 3922338 (1975-11-01), Estevenel et al.
Chem. Abstr. 87 #141233m (1977), 86 #150629(b) #8593s (1977), 82 #106135f (1975), 82 #118718m (1975), 80 #10382s (1974).
De Sabata, V. Chem. Abstr. 87 #157026g (1977) of Drugs Pharm. Sci., 1976(3)(Micro-encapsulation), 143-161, "Bioavailability from Microencapsulated Drugs".
Bakan, J. Chem. Abstr. 84 #126673z (1976) of Polym. Sci. Technol., 1975(8) (Polym. Med. Surg.): 213-235, "Microcapsule Drug Delivery Systems".
Chem. Abstracts Index "Capsules", vol. 66 (1967) and vol. 89 (1978) "Microcapsule" entries.

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