Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2007-01-02
2007-01-02
Azpuru, Carlos A. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
Reexamination Certificate
active
10258616
ABSTRACT:
Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are hydrophilic or are made hydrophilic by suitable derivatization, a process for the preparation of said microemulsions and the use thereof.
REFERENCES:
patent: 6861064 (2005-03-01), Laakso et al.
patent: 94 08610 (1994-04-01), None
patent: 99 21533 (1999-05-01), None
M.R. Gasco et al.: “Long-acting delivery systems for peptides reduced plasma testosterone levels in male rats after a single injection” International Journal of Pharmaceutics (Amsterdam), vol. 62, No. 2-3, pp. 119-124 1990.
M. Bello et al.: “Pertechnetate release from a water/oil microemulsion and an aqueous solution after subcutaneous injection in rabbits” Journal of Pharmacy and Pharmacology, vol. 46, No. 6, pp. 508-510.
S. Bjerregaard et al.: “Sustained elevated plasma aprotinin concentration in mice following intraperitoneal injections of w/o emulsions incorporating aprotinin” Journal of Controlled Release, vol. 71, No. 1, pp. 87-98 Mar. 12, 2001.
Autuori Francesco
Bianchini Carlo
Bottoni Giuseppe
Leoni Flavio
Mascagni Paolo
Azpuru Carlos A.
Italfarmaco S.p.A.
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