Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-19
2005-07-19
Pryor, Alton (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
06919372
ABSTRACT:
The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof.The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.
REFERENCES:
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patent: 04356422 (1992-12-01), None
patent: 5-238959 (1993-09-01), None
patent: 9857972 (1998-12-01), None
Hirano et al, Pharmacokinetics and biotransformation of beraprost sodium, 1989, vol. 4, No. 6, pp. 779-792.
Hara Michio
Katsuma Masataka
Mitomi Mitsuo
Saito Katsumi
Takagi Akira
Pryor Alton
Townsend and Townsend / and Crew LLP
Yamanouchi Pharmaceutical Co. Ltd.
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