Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1982-06-01
1985-09-03
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 81, A01N 2512, A61K 3178
Patent
active
045391998
ABSTRACT:
Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.
REFERENCES:
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patent: 3629392 (1971-12-01), Banker et al.
patent: 3679653 (1972-07-01), Schuck et al.
patent: 3764477 (1973-10-01), Lehmann et al.
patent: 3904745 (1975-09-01), Cohen et al.
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Merck Index, 9th Ed., p. 2054.
Bander Erzsebet
Borvendeg Janos
Nagy Laszlo
Orban Erno
Sotinee Tolvay Marta
Egyt Gyogyszervegyeszeti Gyar
Moezie F.
Phillips Delbert R.
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