Sustained release pharmaceutical composition of solid medical ma

Details Sustained release pharmaceutical composition of solid medical ma Sustained release pharmaceutical composition of solid medical ma

1985-10-23

1987-06-16

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 78, 514781, A61K 3174

Patent

active

046735640

ABSTRACT:
Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment); and in the case where the solid medical material in nicardipine, the composition may consist only of the amorphous nicardipine or a salt thereof without the above compound (second embodiment).

REFERENCES:
patent: 4151273 (1979-04-01), Riegelman et al.
patent: 4344934 (1982-08-01), Martin et al.
patent: 4412986 (1983-11-01), Kawata et al.
Chiou et al., J. Pharm. Sci. 60(9):1281-1302, Sep. 1971.
Florence et al., J. Pharm. Pharmac. 28:637-642 (1976).
Yamamoto et al., J. Pharm. Sci 65(10):1484-1488, Oct. 1976.
Nuernberg C.A. 86:8603 V(1977).
Chiou et al, J. Pharm. Sci. 68(10):1224-1229, Oct. 1979.

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