Sustained release pharmaceutical composition

Details Sustained release pharmaceutical composition Sustained release pharmaceutical composition

1990-08-24

1993-04-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424461, 424462, 424468, 424490, 424493, 424494, 424495, 424497, A61K 924, A61K 958

Patent

active

052021289

ABSTRACT:
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a highly acidic pH and provides a constant, relatively faster rate of release at a more alkaline pH such as that of the intestine. Oral administration of the pharmaceutical pellet composition of the present invention to a patient is effective to deliver to the blood levels of active ingredient within the therapeutic range and to maintain such levels over an extended period of time.

REFERENCES:
patent: 4083949 (1978-04-01), Benedikt
patent: 4367217 (1983-01-01), Gruber et al.
patent: 4415547 (1983-11-01), Yu et al.
patent: 4587118 (1986-05-01), Hsiao
patent: 4661162 (1987-04-01), Kurihara et al.
patent: 4708874 (1987-11-01), Haan et al.
patent: 4713248 (1987-12-01), Kjorn et al.
patent: 4786509 (1988-11-01), Chang et al.
patent: 4800087 (1989-01-01), Mehta
patent: 4803080 (1989-02-01), Benedikt et al.
patent: 4851228 (1989-07-01), Zentner et al.

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