Sustained release of superoxide dismutase mimics from...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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C424S400000, C424S422000, C424S423000, C424S424000

Reexamination Certificate

active

07045142

ABSTRACT:
An implantable or insertable medical device is provided which comprises (a) a superoxide dismutase mimic and (b) a polymeric release region. Upon administration to a patient, the polymeric release region controls the release of the superoxide dismutase mimic, which is beneficially selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic. Also provided is a method of making an implantable or insertable medical device.

REFERENCES:
patent: 5403834 (1995-04-01), Malfroy-Camine et al.
patent: 5696109 (1997-12-01), Malfroy-Camine et al.
patent: 5873904 (1999-02-01), Ragheb et al.
patent: 5874421 (1999-02-01), Riley et al.
patent: 6057367 (2000-05-01), Stamler et al.
patent: 6084093 (2000-07-01), Riley et al.
patent: 6096070 (2000-08-01), Ragheb et al.
patent: 6103714 (2000-08-01), Fridovich et al.
patent: 6214817 (2001-04-01), Riley et al.
patent: 6218016 (2001-04-01), Tedeschi et al.
patent: 6290949 (2001-09-01), French et al.
patent: 6306421 (2001-10-01), Kunz et al.
patent: 6541116 (2003-04-01), Michal et al.
patent: 6545097 (2003-04-01), Pinchuk et al.
patent: 6605619 (2003-08-01), Mitchell et al.
patent: 2001/0018072 (2001-08-01), Unger
patent: 2002/0009535 (2002-01-01), Michal et al.
patent: 2002/0128248 (2002-09-01), Salvemini
patent: WO 98/36784 (1998-08-01), None
patent: WO 00/72893 (2000-12-01), None
patent: WO 01/54748 (2001-08-01), None
Kishore Udipi et al., “Modification of Inflammatory Response to Implanted Biomedical Materials in vivo by Surface Bound Superoxide Dismutase Mimics,”Journal of Biomedical Materials Research, vol. 15, No. 4, 2000, pp. 549-560.
Q.J. Xie et al., Study on plated-derived growth factor mRNA and copper-zinc superoxide dismutase mRNA expression changes of aortic artery endothelium with restenosis after aortic artery dilatation treated with buyang huanwu decoction,Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 17, No. 10, Oct. 1997, pp. 611-613. Abstract only.
Jun Luo, “Nitroxides—Metal-Dependent SOD Mimics,” B-180 Medical Laboratories, Free Radical and Radiation Biology Program, University of Iowa, vol. 77, No. 222, Spring 2001, pp. 1-10.
T. Oinuma et al., “Effects of Copper-Zinc Type Superoxide Dismutase on the Proliferation and Migration of Cultured Vascular Smooth Muscle Cells Induced by Oxidized Low Density Lipoprotein,”J. Atheroscler. Thromb., vol. 4, No. 2, 1997, pp. 79-84. Abstract only.
P.F. Li et al., “Differential Effect of Hydrogen Peroxide and Superoxide Anion on Apoptosis and Proliferation of Vascular Smooth Muscle Cells,”Circulation, vol. 96, No. 10, Nov. 18, 1997, pp. 3602-3609. Abstract only.
X.C. Zheng et al., Expression of human superoxide dismutase gene in rat vascular smooth muscle cells and its anti-oxidative effect,Sheng Li Xue Bao, vol. 15, No. 2, Apr. 1999, pp. 199-205. Abstract only.
L.C. Azevedo et al., “Oxidative Stress as a Signaling Mechanism of the Vascular Response to Injury: The Redox Hypothesis of Restenosis,”Cardiovas. Res., vol. 47, No. 3, Aug. 18, 2000, pp. 436-445. Abstract only.
Min Wang, “SOD Mimics,” B180 Med Lab, University of Iowa, vol. 77, No. 222, Spring 2001, pp. 1-10.
Tal Offer et al., “The Pro-Oxidative Activity of SOD and Nitroxide SOD Mimics,”The FASEB Journal, vol. 14, Jun. 2000, pp. 1215-1223.
S Cuzzocrea et al., “Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury,”Pharmacol. Rev., vol. 53, No. 1, Mar. 2001, pp. 135-159.
N. Ahmad et al., “Metal-Independent Putative Superoxide Dismutase Mimics in Chemistry, Biology, and Medicine,”Ecotoxicol. Environ. Saf., vol. 34, No. 2, Jul. 1996, pp. 141-144. Abstract only.
T.P. Kasten et al., “Potentiation of Nitric Oxide-Mediated Vascular Relaxation by SC52608, a Superoxide Dismutase Mimic,”Proc. Soc. Exp. Biol. Med., vol. 208, No. 2, Feb. 1995, pp. 170-177. Abstract only.

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