Sustained release of microcrystalline peptide suspensions

Details Sustained release of microcrystalline peptide suspensions Sustained release of microcrystalline peptide suspensions

2006-08-29

2006-08-29

Woodward, Michael P. (Department: 1615)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

C530S345000, C514S014800

Reexamination Certificate

active

07098305

ABSTRACT:
The invention relates to a method of preventing gel formation of a hydrophobic peptides by contacting the hydrophobic peptide with a counter-ion in an amount and at a molar ratio with the peptide that are sufficient to provide a fluid, milky microcrystalline aqueous suspension of the peptide without formation of a gel. The invention also relates to a fluid, milky microcrystalline aqueous suspension of a hydrophobic peptide and a counter-ion in water, wherein the peptide and counter-ion are present in amounts and at a molar ratio sufficient to form, upon mixing, the suspension without formation of a gel.

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Martindale, the Complete Drug Reference, pp. 322-330, “Insulin” (K. Parfitt, ed., 32nd ed. 1999).

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