Sustained-release nifedipine preparation

Details Sustained-release nifedipine preparation Sustained-release nifedipine preparation

1987-04-21

1988-08-23

Lusignan, Michael R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 78, A61K 914, A61K 926, A61K 952, A61K 958

Patent

active

047659904

ABSTRACT:
A novel sustained-release nifedipine preparation which comprises the following Composition (A) and Composition (B) in a ratio of 15:85 to 50:50 by weight of nifedipine,
Composition (A): a rapid-release preparation containing as an active ingredient nifedipine fine powder having an average particle size of not more than 5.mu.,
Composition (B): a delayed-release preparation containing as the active ingredient nifedipine fine powder having an average particle size of not more than 5.mu. and having a surface coating layer comprising a non-toxic, hardly water-soluble substance and an enteric high molecular compound.

REFERENCES:
patent: 4340582 (1982-07-01), Kriesel et al.
patent: 4343789 (1982-08-01), Kawata et al.
patent: 4404183 (1983-09-01), Kawata et al.

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