Sustained-release multi-granule tablet

Details Sustained-release multi-granule tablet Sustained-release multi-granule tablet

1994-07-15

1996-11-19

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424469, 424470, 424475, 424493, 424494, 514770, 5147723, 514774, 514777, 514781, 514782, A61K 922, A61K 926

Patent

active

055760210

ABSTRACT:
A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.

REFERENCES:
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patent: 3388041 (1968-06-01), Gans
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patent: 4716041 (1987-12-01), Kj.o slashed.rnaes et al.
patent: 4748023 (1988-05-01), Tam as et al.
patent: 5145683 (1992-09-01), Rhodes

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