Sustained release microparticulate caffeine formulation

Details Sustained release microparticulate caffeine formulation Sustained release microparticulate caffeine formulation

1996-08-16

1997-12-23

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424497, 424459, 424462, 424498, 514952, 427214, 427 219, A61K 916, A61K 954, A61K 958, A61K 960

Patent

active

057004846

ABSTRACT:
The present invention relates to compositions and methods for increasing the alertness of an individual through the administration of a stimulant such as xanthine or an xanthine derivative and preferably caffeine. A particular composition has one or more layers containing the stimulant arranged about the cores of microparticles. This allows the composition to release a significant portion of the stimulant within about two hours after administration so that a level of alertness can be readily achieved. Thereafter, the balance of the composition is released within about 6 to 10 hours, so that the stimulant can provide alertness during that time, but then can dissipate to levels which would not affect the individual's ability to sleep. Also, the formulation is carefully designed so that the stimulant does not accumulate in the individual's system.

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