Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-05-27
2008-05-27
Rao, Manjunath (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S468000
Reexamination Certificate
active
07378394
ABSTRACT:
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.
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Fujii Takao
Ikoma Toshiyuki
Miyamoto Yoko
Niimi Jun
Ogawa Yasuaki
Dang Ian
GaleniSearch, Laboratories
Independent Administrative Institution, National Institute For M
Japan Science and Technology Agency
Price Heneveld Cooper DeWitt & Litton LLP
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