Sustained-release microcapsule of amorphous water-soluble pharma

Details Sustained-release microcapsule of amorphous water-soluble pharma Sustained-release microcapsule of amorphous water-soluble pharma

1995-09-28

2000-09-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 424433, 424434, 424436, 424464, 424499, A61K 950, A61F 200, A61F 1300, A61F 902

Patent

active

061174556

ABSTRACT:
A sustained-release microcapsule contains an amorphous water-soluble pharmaceutical agent having a particle size of from 1 nm-10 .mu.m and a polymer. The microcapsule is produced by dispersing, in an aqueous phase, a dispersion of from 0.001-90% (w/w) of an amorphous water-soluble pharmaceutical agent in a solution of a polymer having a wt. avg. molecular weight of 2,000-800,000 in an organic solvent to prepare an s/o/w emulsion and subjecting the emulsion to in-water drying.

REFERENCES:
patent: 3853837 (1974-12-01), Fujino et al.
patent: 3972859 (1976-08-01), Fujino et al.
patent: 4008209 (1977-02-01), Fujino et al.
patent: 4086219 (1978-04-01), Wittle
patent: 4087390 (1978-05-01), Shields
patent: 4093574 (1978-06-01), Shields
patent: 4100117 (1978-07-01), Shields
patent: 4124577 (1978-11-01), Tinney et al.
patent: 4229438 (1980-10-01), Fujino et al.
patent: 4253997 (1981-03-01), Sarantakis
patent: 4253998 (1981-03-01), Sarantakis
patent: 4277394 (1981-07-01), Fujino et al.
patent: 4317815 (1982-03-01), Coy et al.
patent: 4954298 (1990-09-01), Yamamoto et al.
patent: 5330767 (1994-07-01), Yamamoto et al.
patent: 5622657 (1997-04-01), Takada et al.
American Association for the Advancement of Science, J. Folkman et al., Aug. 1983, pp. 719-725, "Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone".
Journal of Pharmaceutical Sciences, G. Spenlehauer et al., vol. 75, No. 8, Aug. 1986, "Formation and Characterization of Cisplatin Loaded Poly(d,i-Lactide) Microspheres for Chemoembolization".
Proceedings of the National Academy of Sciences, T. W. Redding and A. V. Schally, vol. 78, No. 10, pp. 6509-6512, Oct. 1981, "Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone".
Endocrinology, vol. 93, No. 6, Dec. 1973, Geoffrey W. Tregear et al., "Bovine Parathyroid Hormone: Minimum Chain Length of Synthetic Peptide Required for Biological Activity".

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